Endocrine Abstracts

Hypercalcaemia in pregnancy is associated with foetal (IUGR, miscarriage and preterm delivery), maternal (hypercalcaemic crisis, pre-eclampsia, and hyperemesis) and neonatal complications, with severity of hypercalcaemia correlating with the risk of complications. The true incidence of primary hyperparathyroidism in pregnancy is unknown.A 32 year old lady (G6 P5) with known MEN 1 and associated primary hyperparathyroidism (peak calcium 3.30 mmol/l) ...

Introduction: Immunotherapy has transformed the outcomes of various cancers. Monoclonal antibodies against cytotoxic T lymphocyte antigen 4 (CTLA4), programmed cell death 1 (PD1) and its ligand, PDL1 target mainly T cells, unleashing the immune system against tumour cells. Immune checkpoint inhibitor therapy results in a variety of immune related adverse events, including various endocrinopathies. Thyroid disorders, pituitary disorders are relatively more common compared to pr...